Design,synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones |
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| Authors: | Bin Pan Ren-Zheng Huang Shi-Qing Han Di Qu Ming-Li Zhu Ping Wei Han-Jie Ying |
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| Affiliation: | 1. College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;2. Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Pulic Health, Institute of Medical Microbiology and Institutes of Biomedical Sciences, Shanghai Medical School of Fudan University Box 228, Shanghai 200032, China |
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| Abstract: | A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure–activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one. |
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