Neolignans from Piper kadsura and their anti-neuroinflammatory activity |
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Authors: | Ki Hyun Kim Jung Wook Choi Sang Keun Ha Sun Yeou Kim Kang Ro Lee |
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Institution: | 1. Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea;2. East–West Medical Science Integrated Research Center, Graduate School of East–West Medical Science, Kyung Hee University, #1 Seocheon-dong, Kihung-ku, Yongin-City, Kyungki-Do 446-701, Republic of Korea |
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Abstract: | Bioassay-guided column chromatographic separation of the methanolic extract of dried aerial parts of Piper kadsura (Piperaceae) led to the isolation of a new neolignan, piperkadsin C (1), together with eight known neolignans (2–9). The structures of the isolated compounds were elucidated by combined spectroscopic methods. The anti-neuroinflammatory activities of these compounds were evaluated by assessing nitric oxide (NO) production in LPS-activated BV-2 cells, a microglia cell line. Piperkadsin C (1) and futoquinol (2) potently inhibited NO production with an IC50 value of 14.6 and 16.8 μM in microglia cells, respectively. Compounds 3, 4, 5, 8, and 9 also exhibited moderate inhibition of NO production in BV-2 cells. |
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