|
|||||
|
|
Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid |
|
| Authors: | Iontcho R. Vlahov Gregory D. Vite Paul J. Kleindl Yu Wang Hari Krishna R. Santhapuram Fei You Stephen J. Howard Soong-Hoon Kim Francis F.Y. Lee Christopher P. Leamon |
| Affiliation: | 1. Endocyte Inc., 3000 Kent Ave., Suite A1-100, West Lafayette, IN 47906, USA;2. Bristol-Myers Squibb Research, PO Box 4000, Princeton, NJ 08543, USA |
| Abstract: | Efficient regioselective syntheses of conjugates of folic acid and cytotoxic agents derived from natural epothilones are described. These folate receptor (FR) targeting compounds are water soluble and incorporate a hydrophilic peptide-based spacer unit and a reducible self-immolative disulfide-based linker system between the FR-targeting ligand and the parent drug. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |