Synthesis and anticancer activities of ageladine A and structural analogs |
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| Authors: | Yuelong Ma Sangkil Nam Richard Jove Kenichi Yakushijin David A Horne |
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| Institution: | Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, CA 91010, United States |
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| Abstract: | A series of ageladine A analogs that include 2-aminoimidazo4,5-c]azepines (seven-membered rings) and 2-amino-3H-imidazo4,5-c]pyridine (six-membered rings) derivatives were synthesized and evaluated for their anticancer effects against several human cancer cell lines and MMP-2 inhibition in vitro. Only compounds possessing the aromatic azepine (seven-membered ring) core showed anticancer activity with IC50 values in the low micromolar range. |
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