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Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases
Authors:Li-Xia Cheng  Jiang-Jiang Tang  Hui Luo  Xiao-Ling Jin  Fang Dai  Jie Yang  Yi-Ping Qian  Xiu-Zhuang Li  Bo Zhou
Institution:1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China;2. School of Medicine, Jinggangshan University, Ji′an, Jiangxi 343009, China
Abstract:Eight hydroxyl-substituted Schiff bases with the different number and position of hydroxyl group on the two asymmetric aromatic rings (A and B rings) were prepared by the reaction between the corresponding aromatic aldehyde and aniline. Their antioxidant effects against the stable galvinoxyl radical (GOradical dot) in ethyl acetate and methanol, and 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced DNA strand breakage, and their antiproliferative effects on human hepatoma HepG2 cells, were investigated. Structure–activity relationship analysis demonstrates that o-dihydroxyl groups on the aromatic A ring and 4-hydroxyl group attached to the aromatic B ring contribute critically to the antioxidant and antiproliferative activities.
Keywords:
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