Synthesis of selenophene derivatives as novel CHK1 inhibitors |
| |
Authors: | Pao-Chiung Hong Li-Jung Chen Tzu-Yun Lai Huei-Yu Yang Shih-Jan Chiang Yann-Yu Lu Ping-Kuei Tsai Hung-Yi Hsu Win-Yin Wei Chu-Bin Liao |
| |
Institution: | Development Center for Biotechnology, No. 101, Lane 169, Kangning St., Xizhi City, Taipei County 221, Taiwan |
| |
Abstract: | A series of selenophene derivatives 3 were synthesized as potential CHK1 inhibitors. The effects of substitution on the 4′- or 5′-position of selenophene moiety and shifting the hydroxyl group position on C6- phenolic ring of oxindole were explored. This study led to the discovery of the most potent CHK1 inhibitors 29–33 and 39–43, which had IC50 values in the subnanomolar range. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|