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Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists |
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| Authors: | Nils Griebenow Lars Bärfacker Heinrich Meier Dirk Schneider Nicole Teusch Klemens Lustig Raimund Kast Peter Kolkhof |
| Institution: | 1. Bayer Schering Pharma AG, Global Drug Discovery, Medicinal Chemistry Wuppertal, Building 460, D-42096 Wuppertal, Germany;2. Bayer Schering Pharma AG, Global Drug Discovery, Cell Biology, Building 456, D-42096 Wuppertal, Germany;3. Bayer Schering Pharma AG, Global Drug Discovery, Research Pharmacokinetics, Building 468, D-42096 Wuppertal, Germany;4. Bayer Schering Pharma AG, Global Drug Discovery, Cardiology Research, Building 500, D-42096 Wuppertal, Germany |
| Abstract: | Potent and selective adenosine A1 receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed. |
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