Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 |
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| Authors: | John B Bremner Paul A Keller Stephen G Pyne Timothy P Boyle Zinka Brkic Dorothy M David Mark Robertson Kittiya Somphol Dean Baylis Jonathan A Coates John Deadman Darshini Jeevarajah David I Rhodes |
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| Institution: | 1. School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia;2. Avexa Ltd, 576 Swan St, Richmond, Vic 3121, Australia |
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| Abstract: | An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9–3.9 μg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 μg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2 μg/mL against vancomycin-resistant strains of enterococci (VRE). |
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