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Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones |
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| Authors: | Anna Mrozek-Wilczkiewicz Danuta S Kalinowski Robert Musiol Jacek Finster Agnieszka Szurko Katarzyna Serafin Magdalena Knas Sishir K Kamalapuram Zaklina Kovacevic Josef Jampilek Alicja Ratuszna Joanna Rzeszowska-Wolny Des R Richardson Jaroslaw Polanski |
| Institution: | 1. Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40006 Katowice, Poland;2. Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia;3. Department of Solid State Physics, Institute of Physics, University of Silesia, PL-40007 Katowice, Poland;4. Department of Experimental and Clinical Radiobiology, Center of Oncology-M. Sklodowska-Curie Memorial Institute, PL-44101 Gliwice, Poland;5. Zentiva a.s., CZ-10237 Prague 10, Czech Republic;6. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, CZ-61242 Brno, Czech Republic |
| Abstract: | A group of styrylazanaphthalenes and azanaphthalenediones were synthesized and tested for their anti-proliferative activity. Most of the compounds were obtained with the use of microwave-assisted synthesis. The lipophilicity of the compounds was measured by RP-HPLC and their anti-proliferative activity was assayed against the human SK-N-MC neuroepithelioma and HCT116 human colon carcinoma cell lines. Active compounds were also tested in clonogenity and comet assays. Several quinazolinone and styrylquinazoline analogues were found to have markedly greater anti-proliferative activity than desferoxamine and cis-platin. |
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