Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI |
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| Authors: | Zili Sideratou Dimitris Tsiourvas Theodossis Theodossiou Michael Fardis Constantinos M Paleos |
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| Institution: | 1. Institute of Physical Chemistry, NCSR ‘Demokritos’, 15310 Aghia Paraskevi, Attiki, Greece;2. Institute of Materials Science, NCSR ‘Demokritos’, 15310 Aghia Paraskevi, Athens, Greece |
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| Abstract: | Based on a commercially available hyperbranched aliphatic polyester, novel multifunctional gadolinium complexes were prepared bearing protective PEG chains, a folate targeting ligand and EDTA or DTPA chelate moieties. Their relatively high water relaxivity values coupled with biodegradability of the hyperbranched scaffold, folate receptor specificity render these non-toxic dendritic polymers promising candidates for MRI applications. |
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