Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m |
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| Authors: | André Luís Branco de Barros Valbert Nascimento Cardoso Luciene das Graças Mota Ricardo José Alves |
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| Affiliation: | Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil |
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| Abstract: | Three carbohydrate derivatives, MAG3-Gl, MAG3-Ga, MAG3-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, 99mTc-MAG3-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of 99mTc-MAG3-Ga to assess hepatic function can be considered. |
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