首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Interaction of heparin with cationic molecular probes: Probe charge is a major determinant of binding stoichiometry and affinity
Authors:Helga Szelke  Sarah Schübel  Job Harenberg  Roland Krämer
Institution:1. University of Heidelberg, Inorganic Chemistry Institute, 69120 Heidelberg, Germany;2. University of Heidelberg, Medical Faculty of Mannheim, Institute of Experimental and Clinical Pharmacology and Toxicology, 68169 Mannheim, Germany
Abstract:Fluorescent perylenediimide probes modified with 2, 4, 6, or 8 ammonium groups were synthesized and their binding to the antithrombotic drug heparin was studied by fluorescence spectroscopy in solution. The polyanionic polysaccharide strands of heparin bind more probe molecules per sugar unit when the charge of the latter is low, and stability of the probe-heparin complex increases with increasing probe charge.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号