The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens |
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| Authors: | NamHui Yim Do Thi Ha Trinh Nam Trung Jin Pyo Kim SangMyung Lee MinKyeun Na HyunJu Jung Hyun Su Kim Young Ho Kim KiHwan Bae |
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| Affiliation: | 1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;2. National Institute of Medicinal Materials, 3B Quangtrung, Hoankiem, Hanoi, Viet Nam;3. KT&G Central Research Institute, Daejeon 305-805, Republic of Korea;4. Colloge of Pharmacy, Yeungnam University, Gyeongbuk 712-749, Republic of Korea;5. Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Jeonbuk 570-749, Republic of Korea;6. Department of Pharmaceutical Engineering, Gyeongnam 660-759, Republic of Korea |
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| Abstract: | Nine compounds isolated from the leaf and stem of Vitis amurensis Rupr. (Vitaceae) were evaluated for their antimicrobial activity against two oral pathogens, Streptococcus mutans and Streptococcus sanguis, which are associated with caries and periodontal disease, respectively. The results of several antimicrobial tests, including MIC, MBC, and TBAI, showed that three compounds inhibited the growth of the test bacteria at concentrations ranging from 12.5 to 50 μg/mL. Among these compounds, compound 5, trans-ε-viniferin, displayed the strongest activity against S. mutans and S. sanguis with MIC values of 25 and 12.5 μg/mL, respectively. This is the first report on the antimicrobial activity of stilbenes and oligostilbenes isolated from the leaf and stem of V. amurensis. Thus, this result suggests that natural antimicrobial compounds derived from V. amurensis may benefit oral health as plaque-control agents for the prevention of dental caries and periodontal disease. |
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