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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors |
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| Authors: | Michael B Wallace Mark E Adams Toufike Kanouni Clifford D Mol Douglas R Dougan Victoria A Feher Shawn M O’Connell Lihong Shi Petro Halkowycz Qing Dong |
| Institution: | Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121, United States |
| Abstract: | A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties. |
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