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Effect of goniothalamin on the development of Ehrlich solid tumor in mice |
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| Authors: | Débora Barbosa Vendramini-Costa Ilton Barros Daltro de Castro Ana Lúcia Tasca Góis Ruiz Cilene Marquissolo Ronaldo Aloise Pilli João Ernesto de Carvalho |
| Institution: | 1. Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil;2. Divisão de Farmacologia e Toxicologia, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA), UNICAMP, CP 6171, 13083-970 Campinas, SP, Brazil;3. Departamento de Química Orgânica, Instituto de Química, UNICAMP, CP 6154, 13083-970 Campinas, SP, Brazil |
| Abstract: | In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. |
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