Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis |
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| Authors: | Jun-ichi Kuroyanagi Kazuo Kanai Yuuichi Sugimoto Tetsunori Fujisawa Chikanori Morita Takashi Suzuki Katsuhiro Kawakami Makoto Takemura |
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| Institution: | 1. Lead Discovery & Optimization Research Laboratories II, Daiichi Sankyo Co., Ltd, 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan;2. Technical Department, Daiichi Fine Chemical Co., Ltd, 530 Chokeiji, Takaoka, Toyama 933-8511, Japan |
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| Abstract: | Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species. |
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