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The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands |
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| Authors: | Lidiya Stavitskaya Michael J Seminerio Marilyn M Matthews-Tsourounis Rae R Matsumoto Andrew Coop |
| Institution: | 1. Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA;2. Department of Basic Pharmaceutical Sciences, West Virginia University, PO Box 9500, 2036 Health Sciences North, Morgantown, WV 26506, USA |
| Abstract: | A series of pyridylpiperazines was synthesized and analyzed for sigma receptor binding affinity to determine the optimal pyridyl nitrogen position and chain length for the σ1 and σ2 receptor recognition. The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor σ1 receptors, while previously studied (2-pyridyl)piperazines favor σ2 receptors. |
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