Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity |
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| Authors: | Ki Hyun Kim Il Kyun Lee Cheng Jie Piao Sang Un Choi Jei Hyun Lee Yeong Shik Kim Kang Ro Lee |
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| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea;2. Korea Research Institute of Chemical Technology, Taejeon 305-600, Republic of Korea;3. College of Oriental Medicine, Dongguk University, Gyeong Ju 780-714, Republic of Korea;4. Natural Products Research Institute, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Republic of Korea |
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| Abstract: | Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A–C (2–4), along with 10 known alkaloids (5–14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1–14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC50 = 8.34, 5.14, 7.87, and 2.86 μM, respectively). The four new compounds (1–4) exhibited selective cytotoxicity against the HCT-15 cell line. |
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