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Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives |
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| Authors: | Karem Shanab Eva Schirmer Heike Knafl Eva Wulz Wolfgang Holzer Helmut Spreitzer Peter Schmidt Babette Aicher Gilbert Müller Eckhard Günther |
| Affiliation: | 1. Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;2. AeternaZentaris GmbH, Weismuellerstrasse 50, 60314 Frankfurt, Germany |
| Abstract: | A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated. |
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