Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus |
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| Authors: | Raed A Al-Qawasmeh Mario Huesca Venkata Nedunuri Robert Peralta Jim Wright Yoon Lee Aiping Young |
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| Institution: | 1. Department of Chemistry, The University of Jordan, Amman 11942, Jordan;2. Lorus Therapeutics Inc., 2 Meridian Road, Toronto, Canada M9W 4Z7 |
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| Abstract: | A new series of antimicrobial derivatives 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against Gram-negative bacteria. |
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