S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus |
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| Authors: | Yang Liu Yi Xia Wei Li Mei Cong Alain Maggiani Pieter Leyssen Fanqi Qu Johan Neyts Ling Peng |
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| Affiliation: | 1. State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China;2. Département de Chimie, CINaM CNRS UPR 3118, 163, Avenue de Luminy, 13288 Marseille Cedex 09, France;3. Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium |
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| Abstract: | Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via SNAr-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides. |
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