Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM |
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| Authors: | Thomas M Bridges J Phillip Kennedy Hyekyung P Cho Micah L Breininger Patrick R Gentry Corey R Hopkins P Jeffrey Conn Craig W Lindsley |
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| Institution: | 1. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;2. Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA;3. Vanderbilt Program in Drug Discovery, Nashville, TN 37232, USA;4. Vanderbilt Specialized Chemistry Center(MLPCN), Nashville, TN 37232, USA |
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| Abstract: | This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M5-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan Gq mAChR M1, M3, M5 PAM. An iterative library synthesis approach delivered the first selective M5 PAM (no activity at M1–M4 @ 30 μM), and an important tool compound to study the role of M5 in the CNS. |
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