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Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists |
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| Authors: | Abdul Rehman Ajay Soni Keshav Naik Sreeji Nair Venkata P Palle Sunanda Dastidar Abhijit Ray MS Alam Mohammad Salman Ian A Cliffe Viswajanani Sattigeri |
| Institution: | 1. Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India;2. Department of Pharmacology, New Drug Discovery Research, Ranbaxy Research Laboratories, Plot 20, Sector 18, Gurgaon 122015, Haryana, India;3. Department of Chemistry, Jamia Hamdard, New Delhi 110062, India |
| Abstract: | A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities. |
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