|
|||||
|
|
GPR109a agonists. Part 2: Pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a |
|
| Authors: | Jason E. Imbriglio Sookhee Chang Rui Liang Subharekha Raghavan Darby Schmidt Abby Smenton Scott Tria Thomas O. Schrader Jae-Kyu Jung Craig Esser Tom G. Holt Michael S. Wolff Andrew K.P. Taggart Kang Cheng Ester Carballo-Jane M. Gerard Waters James R. Tata Steven L. Colletti |
| Affiliation: | 1. Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065-0900, United States;2. Department of Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065-0900, United States;3. Department of Cardiovascular Diseases, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065-0900, United States;4. Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, United States |
| Abstract: | 5-Alkyl and aryl-pyrazole-acids have been identified as a new class of selective, small-molecule, agonists of the human orphan G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |