New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides |
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| Authors: | Satoru Tamura Bruno Kilunga Kubata Sawako Itagaki Toshihiro Horii Muzele Kalulu Taba Nobutoshi Murakami |
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| Institution: | 1. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan;2. Department of Biology and Environmental Management, University of Kinshasa, Kinshasa XI, Democratic Republic of the Congo;3. Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan;4. Faculty of Sciences, University of Kinshasa, Kinshasa XI, Democratic Republic of the Congo |
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| Abstract: | A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher’s method and chemical correlation. |
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