1. Zydus Research Centre, Sarkhej-Bavla N.H 8A Moraiya, Ahmedabad 382 210, India;2. Department of Chemistry, Faculty of Science, M. S. University of Baroda, Vadodara 390 002, India
Abstract:
Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARα agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part of a previously reported compound 3. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARα in vitro. These compounds found effective in reducing serum triglycerides (TG) in vivo.