Relationships between structures of hydroxyflavones and their antioxidative effects |
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Authors: | Jiye Hyun Yoonkyung Woo Do-seok Hwang Geunhyeong Jo Sunglock Eom Younggiu Lee Jun Cheol Park Yoongho Lim |
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Affiliation: | 1. Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea;2. National Institute of Animal Science, Rural Development Administration, Suwon 441-706, Republic of Korea |
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Abstract: | Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3′,4′-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure–activity relationships were examined. |
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