Neopetrosiamine A,biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima |
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Authors: | Xiaomei Wei Karinel Nieves Abimael D Rodríguez |
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Institution: | Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan 00931-3346, Puerto Rico |
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Abstract: | A new tetracyclic bis-piperidine alkaloid, neopetrosiamine A (1), has been extracted from the marine sponge Neopetrosia proxima collected off the west coast of Puerto Rico. The structure of compound 1 was elucidated by analysis of spectroscopic data coupled with careful comparisons of its 1H and 13C NMR data with those of a well-known 3-alkylbis-piperidine alkaloid model. The new alkaloid displayed strong in vitro cytotoxic activity against a panel of cancer cell lines as well as in vitro inhibitory activity against the pathogenic microbes Mycobacterium tuberculosis and Plasmodium falciparum. |
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