|
|||||
|
|
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs |
|
| Authors: | Congde Huo Huanjie Yang Qiuzhi Cindy Cui Q. Ping Dou Tak Hang Chan |
| Affiliation: | 1. Department of Chemistry, McGill University, Montreal, Quebec, Canada;2. The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI, USA;3. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China |
| Abstract: | A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |