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Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs |
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| Authors: | Congde Huo Huanjie Yang Qiuzhi Cindy Cui Q Ping Dou Tak Hang Chan |
| Institution: | 1. Department of Chemistry, McGill University, Montreal, Quebec, Canada;2. The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI, USA;3. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China |
| Abstract: | A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT. |
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