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2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors |
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| Authors: | Jiaqiang Cai D. Jonathan Bennett Zoran Rankovic Maureen Dempster Xavier Fradera Jonathan Gillespie Iain Cumming William Finlay Mark Baugh Sylviane Boucharens John Bruin Kenneth S. Cameron William Hamilton Jennifer Kerr Emma Kinghorn George McGarry John Robinson Paul Scullion Joost C.M. Uitdehaag Mario van Zeeland Eric Nicolai |
| Affiliation: | 1. Merck Research Laboratories, MSD, Newhouse, Lanarkshire ML1 5SH, UK;2. Merck Research Laboratories, MSD, 5340BH Oss, The Netherlands;3. Cerep, 19 Avenue du Quebec, 91951 Courtaboeuf Cedex, France |
| Abstract: | Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors. |
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