|
|||||
|
|
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors |
|
| Authors: | Jiaqiang Cai D Jonathan Bennett Zoran Rankovic Maureen Dempster Xavier Fradera Jonathan Gillespie Iain Cumming William Finlay Mark Baugh Sylviane Boucharens John Bruin Kenneth S Cameron William Hamilton Jennifer Kerr Emma Kinghorn George McGarry John Robinson Paul Scullion Joost CM Uitdehaag Mario van Zeeland Eric Nicolai |
| Institution: | 1. Merck Research Laboratories, MSD, Newhouse, Lanarkshire ML1 5SH, UK;2. Merck Research Laboratories, MSD, 5340BH Oss, The Netherlands;3. Cerep, 19 Avenue du Quebec, 91951 Courtaboeuf Cedex, France |
| Abstract: | Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |