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Fragment-based discovery and optimization of BACE1 inhibitors |
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| Authors: | James Madden Jenny R. Dod Robert Godemann Joachim Kraemer Myron Smith Marion Biniszkiewicz David J. Hallett John Barker Jane D. Dyekjaer Thomas Hesterkamp |
| Affiliation: | 1. Evotec UK Ltd, 114 Milton Park, Abingdon OX14 4SA, UK;2. Evotec AG, Schnackenburgallee 114, 22525 Hamburg, Germany |
| Abstract: | A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed. |
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