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Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities |
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| Authors: | Francis Giraud Pascal Marchand Delphine Carbonnelle Michael Sartor François Lang Muriel Duflos |
| Affiliation: | 1. Université de Nantes, Nantes Atlantique Universités, Laboratoire de Chimie Thérapeutique, Cibles et Médicaments des Infections, de l’Immunité et du Cancer, IICiMed UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, 44035 Nantes, France;2. Université de Nantes, Nantes Atlantique Universités, Département de Pharmacologie, Cibles et Médicaments des Infections, de l’Immunité et du Cancer, IICiMed UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, 44035 Nantes, France |
| Abstract: | N-Aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo. |
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