Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis |
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| Authors: | Jong Yeon Hwang David Smithson Michele Connelly Julie Maier Fangyi Zhu Kiplin R Guy |
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| Institution: | St Jude Children’s Hospital, Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA |
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| Abstract: | A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells. |
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