InCl3 mediated one-pot multicomponent synthesis,anti-microbial,antioxidant and anticancer evaluation of 3-pyranyl indole derivatives |
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| Authors: | Neelakandan Vidhya Lakshmi Prakasam Thirumurugan KM Noorulla ParamasivanT Perumal |
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| Institution: | 1. Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, Tamil Nadu, India;2. Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Old Mahabalipuram Road, Jyothi Nagar, Thorapakkam, Chennai, Tamil Nadu, India |
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| Abstract: | A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel–Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl3 in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug. |
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