|
|||||
|
|
Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5 |
|
| Authors: | Mark R Herbert Dana L Siegel Lena Staszewski Charmagne Cayanan Urmi Banerjee Sangeeta Dhamija Jennifer Anderson Amy Fan Li Wang Peter Rix Andrew K Shiau Tadimeti S Rao Stewart A Noble Richard A Heyman Eric Bischoff Mausumee Guha Ayman Kabakibi Anthony B Pinkerton |
| Institution: | 1. Department of Chemistry, Kalypsys, Inc.,10420 Wateridge Circle, San Diego, CA 92121, USA;2. Department of Biology, Kalypsys, Inc.,10420 Wateridge Circle, San Diego, CA 92121, USA;3. Department of Pharmacology, Kalypsys, Inc.,10420 Wateridge Circle, San Diego, CA 92121, USA;4. Department of Drug Metabolism and Pharmacokinetics, Kalypsys, Inc.,10420 Wateridge Circle, San Diego, CA 92121, USA |
| Abstract: | Optimization of a screening hit from uHTS led to the discovery of TGR5 agonist 32, which was shown to have activity in a rodent model for diabetes. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |