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Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine |
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| Authors: | Colin K Skepper Doralyn S Dalisay Tadeusz F Molinski |
| Institution: | 1. Department of Chemistry and Biochemistry, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;2. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA |
| Abstract: | Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure–activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates. |
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