S1P receptor mediated activity of FTY720 phosphate mimics |
| |
Authors: | Klemens Högenauer Klaus Hinterding Peter Nussbaumer |
| |
Institution: | Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland |
| |
Abstract: | Various carboxylic acids, phosphonic acids, sulfonic acids, tetrazoles as well as sulfonylhydantoins were prepared as phosphate mimics of the chiral aminophosphate 1-P to act as agonists on the S1P1 receptor. It was found that amino phosphonates and amino carboxylates are potent S1P1 binders. β-Amino acid 11 could be shown to reversibly reduce blood lymphocyte counts in rats after po administration. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|