A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells |
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| Authors: | Menghua Wang Yi Xia Yuting Fan Palma Rocchi Fanqi Qu Juan L. Iovanna Ling Peng |
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| Affiliation: | 1. State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China;2. Département de Chimie, CNRS UPR 3118 CINaM, 163, avenue de Luminy, 13288 Marseille, France;3. INSERM U624, 163, avenue de Luminy, 13288 Marseille, France |
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| Abstract: | Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action. |
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