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Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE) |
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| Authors: | John Yang Gwendolyn A Marriner Xinyu Wang Phillip D Bowman Sean M Kerwin Salomon Stavchansky |
| Institution: | 1. Division of Pharmaceutics, College of Pharmacy, The University of Texas, Austin, TX 78712, USA;2. US Army Institute of Surgical Research, San Antonio, TX 78234, USA;3. Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712, USA |
| Abstract: | A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection between caffeic acid phenethyl ester (CAPE) and CAPA. |
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