Synthesis and biological evaluation of indolyl chalcones as antitumor agents |
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| Authors: | Dalip Kumar N. Maruthi Kumar Kanako Akamatsu Eriko Kusaka Hiroshi Harada Takeo Ito |
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| Affiliation: | 1. Birla Institute of Technology and Science, Pilani 333 031, India;2. Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan;3. Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan |
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| Abstract: | A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b–d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC50 values 0.03 and 0.09 μM, against PaCa-2 cell line, respectively. |
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