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Discovery of GS-9131: Design,synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148 |
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| Authors: | Richard L. Mackman Adrian S. Ray Hon C. Hui Lijun Zhang Gabriel Birkus Constantine G. Boojamra Manoj C. Desai Janet L. Douglas Ying Gao Deborah Grant Genevieve Laflamme Kuei-Ying Lin David Y. Markevitch Ruchika Mishra Martin McDermott Rowchanak Pakdaman Oleg V. Petrakovsky Jennifer E. Vela Tomas Cihlar |
| Affiliation: | Departments of Medicinal Chemistry, Biology, Drug Metabolism and Clinical Virology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA94404, USA |
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