Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana |
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| Authors: | He Zhong Jiang Xiao Fang Quan Wei Xi Tian Jiang Miao Hu Peng Cheng Wang Sheng Zhuo Huang Zhong Quan Cheng Wen Juan Liang Jun Zhou Xiao Feng Ma You Xing Zhao |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;2. College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing 100049, China;3. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;4. Graduate University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Natural inhibitors of fatty acid synthase (FAS) are emerging as potential therapeutic agents to treat cancer and obesity. The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1–13) mainly including xanthone and benzophenone, in which compounds 7, 8, 9, 10, and 11 were isolated from this plant for the first time and compound 9 was a new natural product. These isolates possess strong inhibitory activity of FAS with the IC50 values ranging from 1.24 to 91.07 μM. The study indicates that two types of natural products, xanthones and benzophenones, could be considered as promising FAS inhibitors. |
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