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Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity |
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| Authors: | Gábor Pintér Ilona Bereczki Gyula Batta Réka Ötvös Ferenc Sztaricskai Erzsébet Rőth Eszter Ostorházi Ferenc Rozgonyi Lieve Naesens Mariann Szarvas Zoltán Boda Pál Herczegh |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary;2. Department of Organic Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary;3. Microbiology Laboratory, Department of Dermatology, Venerology and Dermatooncology, Semmelweis University, Mária u. 41., H-1085 Budapest, Hungary;4. Rega Institute for Medical Research, Katholieke Universiteit, B-3000-Leuven, Belgium;5. IInd Department of Medicine, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary |
| Abstract: | New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against Gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus. |
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