ESI-MS studies on novel liquid homo-peptide libraries and their conjugate libraries directed by phosphorus oxychloride |
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| Authors: | Zhou Ning Hu Li Ming Zhou Gui Ji Liu Yan Lu Kui Zhao Yu Fen |
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| Institution: | (1) College of Chemistry and Engineering, Xiamen University, 361005 Xiamen, P.R. China;(2) Department of Chemistry and Engineering, Zhengzhou Institute of Technology, 450052 Zhengzhou, P.R. China;(3) The Key Laboratory for Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry School of Life Science and Engineering, Tsinghua University, 100084 Beijing, P.R. China |
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| Abstract: | Summary The reactions of natural non-polar amino acids with phosphorus oxychloride were investigated. Some non-polar amino acids,
such as L-Phe, L-Leu and L-Val were treated with phosphorus oxychloride, then quenched with water or some bioactive compounds
(L-menthol, cinchonidine and benzylamine), and yielded the corresponding peptide and peptide conjugate libraries. ESI-MS/MS
was used to study the products of the reaction and confirm the structure of the library. This paper reports a simple method
to synthesize the homo-oligo-peptide libraries and peptide conjugated libraries. |
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| Keywords: | ESP-MS peptide conjugate library peptide library phosphorus oxychloride |
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