Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice |
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| Authors: | Akihiro Asakawa Akio Inui Naohiko Ueno Mineko Fujimiya Masayuki A. Fujino Masato Kasuga |
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| Affiliation: | a Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650, Japan;b Department of Anatomy, Shiga University of Medical School, Tsukinowa-cho, Seta, Otsu 520-2192, Japan;c First Department of Internal Medicine, Yamanashi Medical University, Tamaho, Nakakoma, Yamanashi 409-38, Japan |
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| Abstract: | This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (ICV) injection of mPP (0.003–3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after ICV injection and continued for 4 h. The intraperitoneal (IP) injection of mPP (0.03–30 nmol) dose-dependently decreased food intake. A significant decrease was observed 20 min after IP injection and continued for 4 h. In the elevated plus maze test, the ICV injection of mPP (0.003–3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice. |
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| Keywords: | Mouse pancreatic polypeptide Food intake Anxiety Y4 receptor |
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