神经肽Y(NPY)的生理功能研究进展

神经肽Y(NPY)是机体内的一种重要且保守的神经递质,一般以前体形式存在,释放的有活性的NPY主要通过与其受体结合发挥作用。NPY受体包含了亚型Y1、Y2、Y3、Y4、Y5、Y6、Y7、Y8。Y1和Y2是NPY发挥收缩血管作用的关键受体;Y1、Y2和Y5是NPY调节动物摄食行为的关键受体;Y1、Y2和Y4是NPY调控动物焦虑、沮丧行为的必要受体。着重对NPY与其各种受体结合后如何行使动物的相关生理功能的情况进行了阐述。

Overview on the physiological functions of neuropeptide Y(NPY)

Neuropeptide Y（NPY） is an important neurotransmitter in the body,and very conservative.Generally existing as precursors,after releasing,active NPY could play an important role mainly through binding to receptors.About NPY receptors,there are eight subtypes named Y1,Y2,Y3,Y4,Y5,Y6,Y7 and Y8.Y1 and Y2 are keys in the contraction of blood vessels;Y1,Y2 and Y5 are the key receptors on animal feeding;in anxiety and depression behavior;Y1,Y2 and Y4 are the necessary conditions that NPY regulate animal,depressed behavior.This paper focuses on describing how to play the role of NPY in related physiological functions of animals after binding with receptors.