Synthesis of both enantiomers of 4-vinyl oxazolidin-2-one from a single precursor: D-isoascorbic acid |
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| Authors: | Delle Monache G Misiti D Salvatore P Zappia G |
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| Affiliation: | Centro di Studio per la Chimica dei Recettori e delle Molecole Biologicamente Attive-Istituto di Chimica, Università Cattolica del S. Cuore, Roma, Italy. |
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| Abstract: | A convenient synthesis of (S)- and (R)-4-vinyl oxazolidin-2-one 1 and 2 from the same inexpensive starting material, D-isoascorbic acid, is described. The title compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the literature methods and enhances the synthetic utility of these intermediates. Inc. |
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