Effects of salicylhydroxamic acid on the proliferation of Atriplex and murine neuroblastoma cells, and on Drosophila egg laying and development |
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Authors: | Dutuit Pierre Rouzaire-Dubois Béatrice Talamali Amel Limbourg-Bouchon Bernadette Hours Michel C Dubois Jean-Marc |
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Affiliation: | Laboratoire d'écotechnologie, université Paris-Sud, 1, allée Cérès, 91440 Bures-sur-Yvette, France. pierre.dutuit@u-psud.fr |
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Abstract: | Salicylhydroxamic acid (SHAM) inhibits the proliferation of cultured plant (Atriplex halimus) and murine neuroblastoma cells with IC50 of 90 and 250 microM, respectively. After 2 h of application, SHAM induces an acceleration of the neuroblastoma cell cycle from G1/S to G2 phases and, after 6 h, it induces an accumulation of the cells in S phase and a cell swelling. Up to 300 microM, SHAM is not cytotoxic and does not induce electrophysiological differentiation of neuroblastoma cells. When Drosophila females are grown in media containing 0.6-1.25 mM SHAM, the rate and number of laid eggs are increased. Furthermore, SHAM stimulates the different development stages from embryo to adult. A general interpretation of the effects of SHAM on cell proliferation and differentiation is proposed. |
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Keywords: | Atriplex halimus Murine neuroblastoma Cell cycle Drosophila melanogaster Egg laying and development stagesMots-clé s: Atriplex halimus Neuroblastome murin Cycle cellulaire Drosophila melanogaster Ponte et é tapes de dé veloppement |
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